Association of factor V Leiden R506Q, FXIIIVal34Leu, and MTHFR C677T polymorphisms with acute myocardial infarction

Abstract Background Acute myocardial infarction (AMI) is a leading cause of death and morbidity around the world. Although association between thrombophilia AMI well-established, controversial data are present on thrombophilic polymorphisms AMI. The aim this study was to investigate three including factor V Leiden ( FVL ), MTHFRC677T (methylenetetrahydrofolate reductase), Coagulation XIIIVal34Leu with in East Iran. Result There were no statistically significant differences patients control groups terms distributions allelic genotypic frequencies FXIIIVal34Leu P -value > 0.05). Subjects who carried CT genotype MTHFR C677T polymorphism at 2.03-fold higher risk for -value: 0.02, OR 1.76, 95% CI 1.07–2.75). Furthermore, 677 < 0.001, β = - 0.90, − 1.33, 047) or 677CC 1.04, 1.47, 0.61) genotypes showed significantly Lower creatinine levels compared having 677TT. No observed other remaining Conclusion Our findings that could contribute susceptibility increase east Iran population. This first examine these